Evidently, not all medicinal plants and herbs used locally are edible. The database also contains detailed information about the. In vitro antidiabetic activity of leaves and seeds of boerhavia diffusa in vitro alpha amylase inhibitory activity in vitro. The present study is aimed at evaluating the antidiabetic activity of chloroform extract of boerhaavia diffusa leaves on. Antidiabetic and hypolipidemic activity of punica granatum. Botanical, pharmacological, phytochemical, and toxicological.
The present study was designed to investigate the glucose uptake of antidiabetic activity crude nhexane,ethanol, methanol and aqueous leaf extracts of. Antidiabetic activity of tinospora cordifolia willd. Chemotherapeutic potential of boerhaavia diffusa linn. Phytochemical, therapeutic, and ethnopharmacological. The phytochemical evaluation showed the presence of flavonoids. Blood glucose level of the normal control rats, stz induced diabetic control rats and diabetic rats treated with glibenclamide and different aqueous extracts dosed at 400 mgkg at different time points 0, 60, 120 and 180 min after oral administration of glucose 2 gkg is shown in figure 1. Anti diabetic activity of the stem bark extract and fractions. Currently, documentations on nigerian indigenous plant foods with anti diabetic properties are either scattered or lacking. Senile rats showed glucose intolerance or even frank diabetes. After four weeks feeding of high energy diet, the rats. Antidiabetic activity of boerhaavia diffusa l effect on hepatic key enzymes in experimental diabetes. It is taken in herbal medicine for pain relief and other uses. Anti diabetic effect of cichorium intybus leaves and plantago ovate seeds in high fat dietstreptozotocin induced diabetic rats.
As all these plant extracts were previously screened for enzyme inhibition and antioxidant activity 16. The fasting blood glucose levels were measured at 0, 1, 2 and 3 hrs after the treatment of ethanol and aqueous extracts. The present study revealed the ethanolic extract has the significant anti diabetic activity in the both in vitro and in vivo models. Anti diabetic and antihyperlipidemic activities of alternanthera sessilis in experimentally induced induction of type 2 diabetes in rats. More number of plant and plant products have been scientifically tested and reported to posses anti diabetic activity 2635 examples of herbal medicines with proven anti diabetic activity plant part used.
Antidiabetic activity of pereskia bleo aqueous extracts in. Jul 11, 2017 anti diabetic and antihyperlipidemic activities of alternanthera sessilis in experimentally induced induction of type 2 diabetes in rats. Materials and methods preparation of plant extract the fresh whole plants of b. A comparison was made between the action of different extracts of p. Plant extracts, anti diabetic, anti cancer, anti oxidant background type 2 diabetes has become a major health problem in both developed and developing countries. Diabetes is a world leading disease, 7th leading cause of death, percentage of people suffering from diabetes throughout the world was 9. Traditional indian and australian medicinal plant extracts were investigated to determine their therapeutic potential to inhibit key enzymes in carbohydrate metabolism, which has relevance to the management of hyperglycemia and type 2 diabetes. Boerhavia diffusa bd is a plant of rasayana category as per ayurvedic claims. Ic 50 values indicated that ethanolic extract of the plant has more scavenging activities and reducing power than. Hirumalima and coworkers evaluated bd leaf extracts juice and lyophilized decoction. Significant reduction in glycaemia was observed only when ginseng was taken 40 min before gc in non diabetic subjects and the same result was seen in diabetic subjects. Phytochemical, therapeutic, and ethnopharmacological overview. The antidiabetic activity of both the extracts were evaluated using alloxan 120 mgkg. Antidiabetic activity of helicteres isora root sama venkatesh1, g.
The herbalists,however, use the aqueous leaf extract to treat diabetes in man unpublished data. Senile rats showed glucose intolerance or even frank diabetes mellitus when compared with adults. Here, we describe a database containing information for anti diabetic plants and their use. Pdf detail study on boerhaavia diffusa plant for its. Despite significant advancement in chemical and biological studies of b. In vitro antidiabetic activity of cardiospermum halicacabum leaves extracts by stalin. Those effects are related mainly to the presence of glutinol and flavonoids, which exert their action on the early phase of the acute inflammatory process through central and peripheral mechanism 9,14. Hence, it has traditionally been used as foods and medicines without noticeable adverse effects. Detail study on boerhaavia diffusa plant for its medicinal. In this aspect, the study was carried out to hypolipidemic effect of the fruit husk of this plant on evaluate the antidiabetic and hypolipidemic activity of. Antidiabetic and hypolipidemic activities of kigelia.
Antidiabetic activity of pereskia bleo aqueous extracts in alloxan induced diabetic rats j pharm res antidiabetic activity of pereskia bleo aqueous extracts in alloxan induced diabetic rats mat darus na and mohamad j institute of biological sciences, faculty of science, university of malaya, 50603 kuala lumpur, malaysia. Thus, this study was undertaken to explore the efficacy of anti diabetic activity oftinospora cordifoliain diabetic rats. In addition, the activity of antioxidant enzymes, e. Diabetes mellitus is a group of metabolic alterations characterized by hyperglycemia resulting from defects in insulin secretion, action or both. Kemelayefa 3 1department of pharmaceutical and medicinal chemistry, niger delta university, wilberforce island, bayelsa state, nigeria. Antidiabetic and antioxidant activity of terminalia. Phytochemical screening and in vitro bioactivities of the extracts of aerial part of.
An oral glucose tolerance test ogtt was also performed in experimental diabetic rats. All the extracts of terminalia catappa produced a significant anti diabetic activity at dose levels of 15th of their lethal doses. Based on the wound healing and anti diarrheal activity present study was carried out to evaluate both anti bacterial and antifungal activity of aforementioned plant 6,7. Anti diabetic herbal extracts modulate mitochondrial complex i activity mitochondrial dysfunction is c mitochondrial dysfunction is considered to be causal in the origin and progression of diabetes. It was extracted up to one week with daily 2 hours stirring with a me. The herbalists, however, use the aqueous leaf extract to treat diabetes in man unpublished data. Rats were randomly divided into 6 groups containing 8 rat in each group. Nambiar 1,2 department of foods and nutrition, faculty of family and community sciences.
Antidiabetic activity of dried extract of tionspora. Antidiabetic activity of dried extract of tionspora cordifolia guduchi ghana and honey in streptozotacin induced diabetic rats sanjay b. Antioxidants thus play an important role to protect the human body against damage by reactive oxygen species lollinger. Based on the wound healing and anti diarrheal activity present study was carried out to evaluate both anti bacterial and antifungal activity. Antidiabetic activity of polyherbal formulation on. The present study was designed to investigate the glucose uptake of antidiabetic activity crude nhexane,ethanol, methanol and aqueous leaf extracts of cardiospermum halicacabum. The present study shows for the first time that the leaf extract of cissampelos pareira cle has potential anti hyperglyaemic activity in fructoseinduced and fructosealoxaninduced diabetic rats as judged from the significant reduction in serum glucose and percent glycosylated haemoglobin. The leaves of boerhavia diffusa are often used as a green vegetable in many parts of india. Evaluation of antidiabetic activity and associated. Antidiabetic properties of cissampelos pareira linn. Induction and screening of anti diabetic activity using alloxan. The database describes medicinal plants having anti diabetic activity with other related information including relevant references. Evaluation of phytochemical and antimicrobial activities.
Anti diabetic activity of terminalia catappa leaf extracts ijpt. Antidiabetic effects of nigerian indigenous plant foodsdiets. The author provides a brief botanical description, distribution, pharmacological properties, and phytochemicals, where appropriate. Thus the claims made by the traditional indian systems of medicine regarding the use of leaves of this plant in the treatment of diabetes were confirmed. Anti diabetic medicinal plants open access journals. The present study was designed to investigate the antihyperlipidemic activity of an aqueous extract of boerhavia diffusa leaves in alloxan diabetic rats. Anti diabetic and antiobesity effects 88 results glucose tolerence the data of the present study showed significant high value in the level of fasting serum glucose of senile rats when compared to that of adults. The evaluation of antidiabetic activity of alcoholic and aqueous extracts of whole plant of daemia extensa r br. Anti diabetic activity of polyherbal formulation on alloxan induced diabetes. In vitro antidiabetic activity of leaves and seeds of. Boerhaavia diffusa belonging to family nyctaginaceae has a wide distribution, occurring on. Shamim hossain, naim hassan, biplab kumar dash, md.
Therefore, the aim of this followup study was to further evaluate the anti diabetic mechanisms of ethanolic extracts of 12 trad. Antidiabetic and analgesic activity of leaves of abutilon. This prompted us to study the antioxidant activity of the species, boerhavia diffusa l. Antidiabetic activity of boerhaavia diffusa l effect on hepatic key. The butanol extract produced maximum anti diabetic activity and is higher than the hypoglycemic activity of glibenclamide in the diabetic rats. Anti diabetic effect was evaluated in alloxaninduced diabetic model 2023. Pharmacognostical, phytochemical and antidiabetic studies on. The plant exhibits a somewhat periodic efficacy, with its maximum activity being noticed in the month of may 1. Antidiabetic activity of polyherbal formulation on alloxan. Evaluation of antidiabetic activity of plants used in western. The world health organization who estimates that more than 180 million people worldwide have diabetes and this number is likely to more than double by 2030 and an estimated 1. Anti diabetic activity of tinospora cordifolia willd. Boerhavia diffusa is a species of flowering plant in the four oclock family which is commonly. The plant exhibits a somewhat periodic efficacy, with its maximum activity being noticed in the month of may.
Plants with antidiabetes mellitus properties presents an exhaustive compilation of the anti diabetes mellitus activities of more than plants occurring worldwide. The purpose of this study was to investigate the effects of daily oral administration of aqueous solution of boerhaavia diffusa l. Antidiabetic activity of mediumpolar extract from the leaves of stevia rebaudiana bert. To evaluate antidiabetic and hypolipidemic activities of kigelia pinnata methanolic flowers extract in streptozotocin stz induced diabetic wistar rat. The diabetic animals were randomly divided into eight groups with 8 rats in each group and treated as follows for 14 days continuously orally. Understanding the power of a plantbased diet to improve diabetes management and in some cases reverse.
The effect of plant extracts in alloxan induced diabetic rats is shown in table 4 and table 5. A dose of 500 mgkg body weight made from aqueous plant extract of a. Alloxan, antidiabetic, antioxidant enzymes, terminalia belerica oxidative stress has significant effect in the causation of diabetes as well as diabetic related complications in human beings1. Evaluation of phytochemical and antimicrobial activities of. With lifestylerelated factors contributing to the progress of the disease, you need to take charge and keep the condition in check. The present work was undertaken to explore the anti diabetic potential of hydroalcoholic leaf extract hse of tetrastigma angustifolia in type 2 diabetic animals. During the single dose study, the results were found to be similar to that of normal animals. Significant reduction in glycaemia was observed only when ginseng was taken 40 min before gc in non diabetic subjects and the same result was seen in diabetic. Antidiabetic activity of pongamia pinnata leaf extracts in. Antidiabetic activity of mediumpolar extract from the leaves. Antidiabetic herbal formulations are considered to be more effective for treatment of diabetes. Ant diabetic activity the antihyperglycemic effects of. As a devastating disease, diabetes is affecting approximately 3% of the population worldwide, 90% of which suffer from type 2 diabetes. Antidiabetic effect of cichorium intybus leaves and plantago.
Anti diabetic activity of dried extract of tionspora cordifolia guduchi ghana and honey in streptozotacin induced diabetic rats sanjay b. In this paper, traditional uses, chemical constituents, and reported pharmacological activities have been summarized to present the chemical and therapeutic potential of this plant. The study results also suggested that the plant extract possessed lower anti diabetic activity than the standard anti diabetic drugs. Free radicals have been implicated in the causation of several diseases such as liver cirrhosis, atherosclerosis, cancer, diabetes, etc. The leaves and flower extracts have shown anti inflammatory activity by only 55. Anti diabetic activity of sida spinosa linn malvaceae slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Plant extracts were used in concentration ranging from 50500 gml and 500 l of 16 mm sodium. Anti diabetic medicinal plants used for diabetes mellitus.
Boerhavia diffusa is a species of flowering plant in the four oclock family which is commonly known as punarnava meaning that which rejuvenates or renews the body in ayurveda, red spiderling, spreading hogweed, or tarvine. Ashrafuzzaman sapon, monokesh kumer sen abstract in the last few years, there has been an exponential growth in the field of herbal medicine and gaining. Evaluation of antidiabetic activity of plants used in. Ic50 of different extracts of leaves and seeds of boerhavia diffusa solvent system plant parts leaves seeds. If you continue browsing the site, you agree to the use of cookies on this website. Antidiabetic activity of boerhaavia diffusa l effect on. Infectious diseases pose serious problems to health and they are main causes of morbidity and mortality worldwide 9. Anti diabetic activity of the stem bark extract and. Anti diabetic and anti obesity effects 88 results glucose tolerence the data of the present study showed significant high value in the level of fasting serum glucose of senile rats when compared to that of adults.
Material and methods plant material the plant tetrastigma angustifolia was collected from the. The antidiabetic activity of pongamia pinnata family. Pulla reddy college of pharmacy, mehdipatnam, hyderabad 500 028. This study aimed to evaluate the hypoglycemic activity and possible toxicity effect of aqueous leaf extract of the herb administered at different dosages for 15 days in streptozotocininduced diabetic. Boerhavia diffusa exhibit potent anti diabetic activity and its leaf extracts with various solvents have shown hypoglycemic activity in normal animals and antihyperglycemic activity in alloxan. The clinical efficiency of many existing antibiotics is being threatened by the emergence of multidrug resistant. Antidiabetic and antioxidant activity of scoparia dulcis linn. Anticonvulsant activity of methanolic extract, 1500 and 2000 mg kg 1, intraperitoneally i. Effect of chronic administration of boerhaavia diffusa linn. The present study was designed to investigate the antidiabetic activity of aqueous extract of acacia tortilis polysaccharide aeatp from gum exudates and its role in comorbidities associated with diabetes in stznicotinamide induced diabetic rats. Antidiabetic assessment of the hydroalcoholic leaf. Thus, this study was undertaken to explore the efficacy of antidiabetic activity oftinospora cordifoliain diabetic rats. Antidiabetic activity and chemical characterization of.
Antidiabetic activity of the leaves extracts of wrightia. The possible mechanism by which this drug may act is discussed in this study. Therefore it is obvious that the fractionation with butanol has enriched the active principles. Type i diabetes often referred to as juvenile diabetes, is insulin dependent and known to affect only 5% of the diabetic.
Rats were made diabetic by a single dose of stz at 60 mgkg body weight i. Antidiabetic activity of mediumpolar extract from the. Invitro screening of anti inflammatory and antidiabetic activity of root extract of argyreia nervosa. Methanol extract showed higher antioxidant, thrombolytic activity and less. Phytochemical screening and in vitro bioactivities of the extracts of. Concurrent histological studies of the pancreas of these animals showed regeneration by aqueous and cold extracts which were earlier necrosed by alloxan. Menaria j the pharmaceutical and chemical journal, 2016, 32. Evaluation of anti diabetic activity of the polyherbal formulation 16. Diabetes is a longterm condition that causes high blood sugar levels over a prolonged period.
Exploring the antidiabetic potential of australian. Male albino wistar rats were divided into control, diabetic control, glimepiride treated 10 mgkg, and diabetic rats treated with 250, 500, and. Natural antioxidant activity of boerhavia diffusa l. Effect of the aqueous extract of boerhavia difusa roots. Anti diabetic and antiobesity effects of plant extract. Plants with antidiabetes mellitus properties crc press book. Bertoni on alloxaninduced diabetic rats bertoni on alloxaninduced diabetic rats himanshu misra, 1, 2 manish soni, 3 narendra silawat, 4 darshana mehta, 1 b. Ethnopharmacological use of roots of boerhaavia diffusa b. Mudgal studied the anti inflammatory effect of aqueous insoluble alcoholic extract of bd in rats. These compounds might be responsible for the anti diabetic activity on the fruits of adansonia digitata linn. Antidiabetic herbal extracts modulate mitochondrial complex. The fasting blood glucose levels in alloxan induced diabetic rats were 340400 mg100 ml. Anti diabetic activity of the stem bark extract and fractions of faidherbia albida del.
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